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Top 10 Prescription Drug Rehab Centers in Charlotte

Prescription drug addiction has become one of the most pressing public health challenges in Charlotte and across North Carolina. From opioid painkillers like oxycodone and hydrocodone to benzodiazepines such as Xanax and Valium, prescription medications can lead to physical dependence and addiction even when taken as directed. The good news is that Charlotte offers a range of specialized treatment centers equipped to address prescription drug dependency through evidence-based medical care, therapy, and long-term recovery support.

Whether you’re seeking outpatient flexibility, medication-assisted treatment (MAT), medically supervised detox, or residential care, finding the right program is essential for lasting recovery. This guide highlights the top 10 prescription drug rehab centers in Charlotte, each offering unique strengths to support individuals and families on the path to healing.

This content is intended to support informed decision-making and is not a ranking or evaluation of treatment outcomes.

Table of Contents

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1. Southeastern Recovery Center

1018 Lee-Ann Dr. NE, Concord, NC 28025

Best For: Comprehensive, individualized prescription drug treatment with trauma-informed care and flexible scheduling.

drug and alcohol rehab facility in charlotte north carolina

Southeastern Recovery Center offers evidence-based treatment for prescription drug addiction, including opioid painkillers and benzodiazepines, through flexible PHP and IOP programs. The center combines medical management, individual and group therapy, and co-occurring disorder support to address the root causes of prescription drug dependency. Their services include detox coordination, residential treatment, outpatient care (also offering virtual IOP), and dual diagnosis support for individuals struggling with both substance use and mental health disorders.

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2. McLeod Centers for Wellbeing​

500 Archdale Dr, Charlotte, NC 28217​

Best For: Early-morning medication-assisted treatment for prescription opioid addiction

front of building McLeod Center for Wellbeing in Charlotte NC

Founded in 1969, McLeod Centers provides prescription drug addiction treatment through residential and outpatient programs. Their early-morning MAT clinic offers Suboxone and other medications before the workday begins, combined with counseling and trauma-informed care. The center treats opioid, benzodiazepine, and stimulant prescription drug dependencies.

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2. Atrium Health Addiction Services

501 Billingsley Rd, Charlotte, NC 28211​

Best For: Prescription drug detox with hospital-level medical monitoring and pain management coordination

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Atrium Health offers medically supervised treatment for prescription opioid and benzodiazepine addiction through intensive outpatient programs within a healthcare system. Services include MAT, individual and group therapy, and coordination with medical specialists, pain management physicians, and psychiatric care. Programs are grounded in evidence-based practices with 12-step recovery support.

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4. The Blanchard Institute

10348 Park Rd, Charlotte, NC 28210​

Best For: Family-centered prescription drug recovery with loved ones involved in benzodiazepine taper planning

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Description: The Blanchard Institute provides treatment for prescription drug addiction with a focus on family involvement throughout recovery. Programs include outpatient medical detox, PHP/IOP, and family therapy sessions that educate and empower loved ones to support sobriety. 

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5. Harmony Recovery Center

8520 Cliff Cameron Drive, Suite 450, Charlotte, NC 28269

Best For: Telehealth prescription drug counseling for opioid and benzo addiction with remote MAT management

Harmony Recovery Center Charlotte Building

Harmony Recovery Center treats prescription opioid, benzodiazepine, and stimulant addiction through PHP, IOP, and MAT programs. The center offers telehealth options alongside in-person care. Evening programs and flexible scheduling accommodate scheduling around family and career obligations while providing addiction and mental health support.

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6. Ascend Recovery Centers

1421 Orchard Lake Drive, Suite C, Charlotte, NC 28270

Best For: Trauma-focused specialty therapies for prescription drug dependency

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Ascend Recovery Centers provides treatment for prescription drug addiction with trauma therapies often unavailable at standard rehab facilities. Programs integrate EMDR, Cognitive Processing Therapy (CPT), and Trauma-Focused CBT alongside PHP, IOP, and MAT services.

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7. New Season Treatment Center – Charlotte

3315 Wilkinson Blvd, Charlotte, NC 28208

Best For: High-dose methadone maintenance programs for severe, long-term opioid prescription drug dependence

Building in Charlotte NC for New Season Treatment Center

New Season Treatment Center specializes in opioid addiction treatment through Medication-Assisted Treatment (MAT) using methadone, buprenorphine (Suboxone), and naltrexone. The center offers methadone maintenance for individuals with severe, chronic opioid dependence, along with individual and group counseling, medically supervised withdrawal support, and flexible take-home medication privileges for clients.

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8. Better Life Partners – Charlotte

7221 Pineville Matthews Rd., Unit 200 Charlotte, NC 28226

Best For: Same-day Suboxone induction for prescription opioid withdrawal without waitlists

Better Life in Charlotte NC, inside of the building

Better Life Partners offers same-day access to Medication-Assisted Treatment (MAT) with Suboxone for prescription opioid addiction within a harm-reduction framework. Services include virtual consultations, patient-directed treatment goals, and entry without requiring abstinence before starting care. The program accepts most insurance, Medicare, Medicaid, and offers a sliding fee scale.

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9. Pyramid Healthcare – Concord

1501 Zion Church Rd E, Concord, NC 28025

Best For: Residential prescription drug detox with Medicaid coverage and extended residential care

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Pyramid Healthcare provides treatment for prescription drug addiction through Medicaid-approved detox, residential, and outpatient services in nearby Concord. The facility offers on-site medical detox for prescription drug withdrawal, followed by residential care and MAT for opioid dependence. Programs include therapy, co-occurring mental health support, and transition planning for long-term recovery.

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10. Rebound Behavioral Health Hospital

134 E Rebound Rd, Lancaster, SC 29720

Best For: Medically supervised benzodiazepine withdrawal with 24/7 seizure prevention protocols

South Carolina Building, Rebound Behavioral Health

Rebound Behavioral Health Hospital specializes in benzodiazepine and prescription drug addiction treatment within an acute psychiatric hospital setting. Services include 24/7 medically supervised detox with seizure protocols, psychiatric crisis stabilization, medication management, and intensive therapy for clients experiencing co-occurring anxiety disorders, panic disorder, or mental health emergencies alongside prescription drug dependence.

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Finding the Right Prescription Drug Rehab in Charlotte​

Prescription drug addiction is a complex medical condition that requires specialized care tailored to each individual’s circumstances. Whether you’re struggling with opioid painkillers prescribed after surgery, benzodiazepines taken for anxiety, or stimulant medications, Charlotte’s top rehab centers offer proven pathways to recovery through medical expertise, compassionate support, and evidence-based treatment.

When choosing a prescription drug rehab center, consider factors such as the level of care needed (outpatient vs. residential), medication-assisted treatment options, schedule flexibility for work obligations, insurance coverage, and specialized services for co-occurring mental health conditions. Many centers offer free consultations to help you determine the best fit for your recovery journey.

Recovery from prescription drug addiction is possible with the right support system and professional treatment. If you or a loved one is ready to take the first step toward freedom from prescription drug dependence, reach out to any of these top-rated Charlotte centers today.

For comprehensive, compassionate prescription drug addiction treatment in Charlotte, contact Southeastern Recovery Center.

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